Vaccine update: issue 315, December 2020, COVID-19 special edition

Vaccine update: issue 315, December 2020, COVID-19 special edition (print version) Ref: PHE gateway number 2020372 PDF, 2.78MB, 21 pages This file may not be suitable for users of assistive technology. Request an accessible format. If you use assistive technology (such as a screen reader) and need a version of this document in a more accessible format, please email publications@phe.gov.uk. Please tell us what format you need. It will help us if you say what assistive technology you use. Source link

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Confirmed cases of COVID-19 variant from South Africa identified in UK

The 2 cases were identified in the UK on 22 December 2020 and both have been in contact with someone who has travelled from South Africa. Public Health England’s Health Protection Teams have followed up with both cases and contact tracing is underway. The new variant named B1.351 (also referred to as 501Y.V2) was first detected in Nelson Mandela Bay, South Africa, in samples at the beginning of October. Molecular dating suggests that it could have been in circulation from the end of August. The rapid spread of the variant in South Africa could be an indication of increased transmissibility but this is not yet confirmed. PHE is…

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Rapid evaluation confirms lateral flow devices effective in detecting new COVID-19 variant

Scientists at PHE’s Porton Down laboratory have carried out a rapid evaluation using clinical and laboratory grown samples containing the VUI 202012/01 variant to test whether it can be detected by lateral flow devices (LFDs) currently in use across the country. Five LFDs were tested. Each device is either in use as part of mass testing or going through the final stages of validation at PHE. Each device successfully detected samples containing the new variant. LFDs are one of the new tools being used to help detect COVID-19 and results can be delivered rapidly in under 30 minutes. The devices can identify people who have high levels of…

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Multiphase optimization strategy (MOST) – GOV.UK

This guidance is part of a guide to evaluating digital health products. Digital health products and services are usually made up of various features (multicomponent interventions). However, they are often assessed as a package and we are unable to tell which components of the interventions are effective and which are non-essential. Multiphase optimization strategy (MOST) involves first evaluating various different components to optimise the intervention. The components with the most promising results are then included in the intervention package while others are discarded. What to use it for Use the MOST approach to assess different elements of your digital product or service. This method is particularly useful when…

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Interrupted time series study – GOV.UK

An interrupted time series (ITS) design involves collecting data consistently before and after an interruption. This means introducing and withdrawing your digital product or service, or some part of it. It is a useful design to demonstrate cause and effect of your digital product without randomising to different conditions – for example, as you would do in a randomised controlled trial. What to use it for Using ITS can help you to find out whether your digital product or service achieves its aims, so it can be useful when you have developed your product (summative evaluation). To use an ITS design, you need 2 things: an intervention that…

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