Immunoglobulin: when to use – GOV.UK

Published 1 October 2008

Last updated 2 October 2020
+ show all updates

  1. Added revised guidance on the use of diphtheria anti-toxin, October 2020

  2. Added: Important information about the Intervax diphtheria anti-toxin Lot 146 and extended use.

  3. Updated general immunoglobulin information.

  4. Updated Rabies and Immunoglobulin Service (RIgS).

  5. Updated ‘Rabies and Immunoglobulin Service: use of approved courier services’.

  6. Added revised hepatitis B immunoglobulin guidance.

  7. Added revised Hepatitis A immunoglobulin guidance.

  8. Added link to revised guidance for health professionals.

  9. RIgS page updated. VZIG documents removed and link to new VZIG page added to the details section.

  10. Added revised Diphtheria Anti-toxin (DAT) guidance for August 2018.

  11. Added revised Diphtheria Anti-toxin (DAT) guidance updated due to DAT supply.

  12. Added revised interim guidance on the use of Diphtheria anti-toxin.

  13. Added document: Updated restrictions on use of VZIG during supply shortage: advice to health professions and RIgs page updated.

  14. Updated to reflect Greenbook changes in Human Rabies Immunoglobulin (HRIG) guidance.

  15. Uploaded interim VZIG guidance for pregnant women exposed to varicella, in relation to current immunoglobulin shortages.

  16. Added details of VZIG restrictions due to shortage.

  17. Updated Chickenpox (varicella-zoster) immunoglobulin guidance to clarify dose of methotrexate on page 10.

  18. Updated hepatitis A immunoglobulin guidance to clarify dosage and timing details.

  19. Updated ‘Chickenpox (varicella-zoster) immunoglobulin May 2017’ guidance by adding ‘methotrexate’ to table on page 12.

  20. Updated Chickenpox (varicella-zoster) immunoglobulin guidance.

  21. Updated rabies and immunoglobulin service guidance.

  22. Updated Chickenpox human varicella-zoster immunoglobulin guidance

  23. Details on an update to the Rabies and Immunoglobulin Service (RIgS).

  24. Updated the diphtheria anti-toxin chapter: the dosage section on page 1 has changed, based on WHO guidance and may differ from the Summary of Product Characteristics (SmPC).

  25. First published.

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